期刊
CELL DEATH AND DIFFERENTIATION
卷 13, 期 2, 页码 179-188出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4401826
关键词
XIAP; drug discovery; small molecules; antisense; apoptosis
X-linked inhibitor of apoptosis protein ( XIAP) is a member of the inhibitor of apoptosis proteins family of caspase inhibitors that selectively binds and inhibits caspases-3, -7 and -9, but not caspase-8. As such, XIAP blocks a substantial portion of the apoptosis pathway and is an attractive target for novel therapeutic agents for the treatment of malignancy. Antisense oligonucleotides directed against XIAP are effective in vitro and are currently being evaluated in clinical trials. Small molecule XIAP inhibitors that target the baculovirus IAP repeat (BIR) 2 or BIR 3 domain are in preclinical development and are advancing toward the clinic. This review will discuss the progress being made in developing antisense and small-molecule XIAP inhibitors.
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