期刊
BIOSYSTEMS
卷 83, 期 2-3, 页码 207-216出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2005.07.006
关键词
systems biology; JWS online; detailed kinetic model; model repository
资金
- Biotechnology and Biological Sciences Research Council [BB/C008219/1, BB/D019079/1] Funding Source: Medline
- BBSRC [BB/D019079/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D019079/1, BB/C008219/1] Funding Source: researchfish
Systems Biology aims to understand quantitatively how properties of biological systems can be understood as functions of the characteristics of, and interactions between their macromolecular components. Whereas, traditional biochemistry focused on isolation and characterization Of cellular components, the challenge for Systems Biology lies in integration of this knowledge and the knowledge about molecular interactions. Computer models play an important role in this integration. We here discuss an approach with which we aim to link kinetic models on small pails of metabolism together, so as to form detailed kinetic models of larger chunks of metabolism, and ultimately of the entire living cell. Specifically, we will discuss techniques that can be used to model a sub-network in isolation of a larger network of which it is a part, while still maintaining the dynamics of the larger complete network. We will start by Outlining the JWS online system, the silicon cell project, and the type of models we propose. JWS online is a model repository, which can be used for the storage, simulation and analysis of kinetic models. We advocate to integrate a top-down approach, where measurements on the complete system are used to derive fluxes in a detailed structural model, with a bottom-up approach, consisting of the integration of molecular mechanism-based detailed kinetic models into the structural model. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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