Conformationally biased P3 amide replacements of β-secretase inhibitors

yWe have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the beta-secretase inhibitor 7m which has an in vitro IC50 = 35 nM. The synthesis and biological activities of these compounds are described. (c) 2005 Elsevier Ltd. All rights reserved.