期刊
STEM CELLS
卷 24, 期 2, 页码 333-336出版社
ALPHAMED PRESS
DOI: 10.1634/stemcells.2005-0201
关键词
stem cells; labeling; homing; positron emission tomography; infarction; heart; implantation
Granulocyte-colony-stimulating factor administered for autologous hematopoietic stem cell isolation from blood may favor restenosis in patients implanted after acute myocardial infarction (AMI). We therefore tested the isolation of peripheral-blood CD34(+) cells without mobilization in six patients with AMI. After large-volume cytapheresis and positive CD34(+) cell selection, 3.6 to 27.6 million CD34(+) cells were obtained. We performed intracoronary implantation of these cells and recorded no restenosis or arrhythmia. We used positron emission tomography (PET) to assess myocardial-labeled CD34(+) cell homing, which accounted for 5.5% of injected cells I hour after implantation. In conclusion, large amounts of CD34(+) cells, in the range reported in previous studies, can be obtained from nonmobilized peripheral blood. PET with [F-18]-fluorodeoxyglucose cell labeling is an efficient imaging method for homing assessment.
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