期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 17, 期 1-2, 页码 29-40出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2005.09.006
关键词
TGF-beta; Smad; cancer; stroma; epithelium; interactions; cross-talk
TGF-beta signaling regulates tumorigenesis and ill human cancer its signaling pathways are often modified during tumor progression. Prior to initiation and early during progression TGF-beta acts upon the epithelium as a tumor Suppressor, however at later stages it is often a tumor promoter. Over the years, many studies have focused on the epithelial cell autonomous role for TGF-beta, however, TGF-beta is not strictly limited to this compartment in vivo. Recent studies addressing TGF-beta mediated stromal-epithelial interactions have significantly improved our understanding related to the regulation of cancer. In addition, stromal fibroblast cell autonomous effects have been observed in response to TGF-beta stimulation. According to the current literature and experimental evidence, TGF-beta is a potent ligand that regulates carcinoma initiation, progression and metastasis through a broad and complex spectrum of interdependent interactions. (c) 2005 Elsevier Ltd. All rights reserved.
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