期刊
CELLULAR IMMUNOLOGY
卷 239, 期 2, 页码 92-102出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2006.04.007
关键词
B cells; maturation; differentiation; homeostasis
资金
- NHLBI NIH HHS [5T32HL007971] Funding Source: Medline
- NIAID NIH HHS [T32 AI055428] Funding Source: Medline
Although it is clear that the final phases of B cell maturation occur after newly formed B cells exit the bone marrow, the mechanisms underpinning the maturation, selection, and long-term survival of immature peripheral B cells remain poorly understood. Here, we review recent advances in our understanding of how B cell receptor (BCR)-mediated signaling events integrate with additional environmental cues to promote the selection and differentiation of immature B cells into functionally distinct subpopulations of mature B cells. We pay particular attention to the role of the Baff cytokine family and the Notch receptor-ligand family and their unique roles in promoting B cell survival and differentiation into follicular and marginal zone B cells. (c) 2006 Elsevier Inc. All rights reserved.
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