期刊
JOURNAL OF ANTIBIOTICS
卷 59, 期 2, 页码 93-97出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2006.13
关键词
sespendole; lipid droplet synthesis; fungal metabolites; Pseudobotrytis terrestris; indolosesquiterpene
Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis of cholesteryl ester and triacylglycerol by mouse macrophages with IC50 values of 4.0 and 3.2 mu M, respectively.
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