期刊
SEMINARS IN CANCER BIOLOGY
卷 16, 期 1, 页码 73-79出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2005.07.009
关键词
regulatory T cells; Treg cells; immune suppression; toll-like receptors; antigen specificity; immunotherapy
类别
Regulatory T-cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Recent Studies demonstrate the existence of CD4(+) regulatory T-cells at tumor sites, implying that these Treg cells may induce antigen-specific and local immune tolerance. This review will discuss the natural ligands and their potential roles of tumor-specific CD4(+) regulatory T-cells in cancer therapy. (c) 2005 Elsevier Ltd. All rights reserved.
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