期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 16, 期 1, 页码 111-118出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2006.01.002
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资金
- NCRR NIH HHS [RR020173] Funding Source: Medline
- NINDS NIH HHS [NS045729, NS045880, NS041596] Funding Source: Medline
Work emerging during the past decade has shown that axons, similar to dendrites, are capable of autonomously generating new proteins through translation of localized mRNAs. Even in mammals, neurons maintain the ability to target mRNAs and translational machinery into the axonal compartment well into adulthood. The biological functions of axonal protein synthesis in adult neurons are just now being revealed, and recent studies indicate that locally synthesized proteins facilitate regeneration. Local translation, in addition to protein degradation, is needed for growth cone formation after axotomy, for generating a retrogradely transported injury signal, and then to help structurally maintain the growing axon. Regulation of axonal protein synthesis by exogenous stimuli might provide a means to facilitate regeneration for neuronal populations that normally show poor regenerative capacity in the adult nervous system.
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