期刊
JOURNAL OF IMMUNOLOGY
卷 176, 期 3, 页码 1439-1446出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.176.3.1439
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资金
- Medical Research Council [MC_U137884177, G116/121] Funding Source: Medline
- Medical Research Council [MC_U137884177, G116/121] Funding Source: researchfish
- MRC [MC_U137884177, G116/121] Funding Source: UKRI
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus. In this study, we show that LEF1 and TCF7 (TCF-1) are not only expressed in thymocytes, but also in mature T cells. Our data demonstrate that Ag encounter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of LEF1 and TCF7 (TCF-1) expression in human naive CD8 T cells. We further show that resting T cells preferentially express inhibitory LEF1 and TCF7 (TCF-1) isoforms and that T cell activation changes the isoform balance in favor of stimulatory TCF7 (TCF-1) isoforms. Altogether, our study suggests that proteins involved in the WNT signaling pathway not only regulate T cell development, but also peripheral T cell differentiation.
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