期刊
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 20, 期 2, 页码 91-94出版社
HINDAWI LTD
DOI: 10.1155/2006/498142
关键词
bilirubin monitoring; duoderogastroesophogeal reflux; gastroesophageal reflux disease; nonerosive reflux disease; pH monitoring
BACKGROUND AND AIM: Patients with gastroesophageal reflux disease (GERD) usually suffer from acid reflux and duodenogastroesophageal reflux (DOER) simultaneously. The question of whether DOER has an important effect on the development of GERD remains controversial. The aim of the present study was to investigate the role of DOER in the pathogenesis of GERD and its value for the diagnosis of nonerosive reflux disease (NERD). METHODS: GERD was initially diagnosed using the reflux disease questionnaire. For further diagnosis, results of the upper gastrointestinal endoscopy (excluding a diagnosis of Barrett's esophagus) were considered in conjunction with Simultaneous 24 h esophageal pH and bilirubin monitoring. RESULTS: According to endoscopic findings, 95 patients (43 men, 50 +/- 10 years of age) were divided into two groups: the reflux esophagitis (RE) group (n=51) and the NERD group (n=44). Three DOER parameters, the percentage of time with absorbance greater than 0.14, the total number of reflux episodes and the number of bile reflux episodes lasting longer than 5 min, were evaluated in the study. For the RE group, the values of the DGER parameters (19.05% +/- 23.44%, 30.56 +/- 34.04 and 5.90 +/- 6.37, respectively) were significantly higher than those of the NERD group (7.26% +/- 11.08%, 15.68 +/- 20.92 and 2.59 +/- 3.57, respectively, P < 0.05 for all) but no significant difference was found in acid reflux. Of NERD patients, 18.5% were diagnosed with simple DGER. The positive diagnosis rate of NERD Could be significantly elevated from 65.9% to 84.1% (P < 0.05), if bilirubin monitoring was employed in diagnosis. CONCLUSIONS: DOER may Occur independently but plays an important role in the development of RE and GERD symptoms. Simultaneous 24 h esophageal pH and bilirubin monitoring is Superior to simple pH monitoring in helping identify, patients at risk for NERD.
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