期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 16, 期 1, 页码 51-59出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2005.12.007
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Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell-cell adhesion and gene transcription. The armadillo repeat protein beta-catenin is an important integrator of both processes. beta-catenin acts in the Writ signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. beta-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of beta-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell-cell adhesion and to the increased transcription of Wnt target genes.
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