期刊
SYNAPSE
卷 59, 期 2, 页码 69-73出版社
WILEY-LISS
DOI: 10.1002/syn.20217
关键词
reward; electrophysiology; behavior; cocaine; self-administration; water
资金
- NIDA NIH HHS [DA14339] Funding Source: Medline
We have previously reported that distinct populations of nucleus accumbens (NAc) neurons differentially encode information about goal-directed behaviors for natural (food/water) vs. cocaine reinforcement [J Neurosci 20:4255-4266, (2000)]. Here, the anatomic distribution of reinforcer-selective cell firing was examined within the core and shell of the NAc. Rats (n = 8) were trained on a multiple schedule for water reinforcement and cocaine (0.33 mg/infusion) self-administration. Next, microelectrode arrays (eight wires/array) were bilaterally positioned in the NAc core and shell, and cell firing was recorded during the multiple schedule. All electrode tip placements were then marked, and histological reconstruction of each electrode position was completed. Of 93 NAc cells, 44 neurons (47%) exhibited 1 of 4 types of well-documented patterned discharges relative to the water- or cocaine-reinforced response. Of the 44 phasic cells, 39 neurons (89%) displayed differential, nonoverlapping neuronal firing patterns across the two reinforcer conditions (i.e., reinforcer-selective activity). Histological reconstruction of electrode placement revealed that NAc patterned discharges, specific to goal-directed behaviors for water or cocaine, were not limited to one NAc subregion but were evenly distributed and intermixed throughout the core and shell. These findings are discussed with respect to the functional organization of the NAc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据