期刊
ORGANIC LETTERS
卷 8, 期 3, 页码 519-522出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol052859x
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资金
- NIGMS NIH HHS [R01-GM69445] Funding Source: Medline
[GRAPHICS] Catalytic hydrogenation of methyl vinyl ketone (MVK) and ethyl vinyl ketone (EVK) in the presence of diverse aldehydes at ambient temperature and pressure using tri-2-furylphosphine-ligated rhodium catalysts enables formation of aldol products with high levels of syn-diastereoselectivity. A progressive increase in diastereoselectivity is observed upon sequential replacement of phenyl residues for 2-furyl residues (Ph3P, FurPh(2)P, Fur(2)PhP, Fur(3)P). Hydrogen-labile functional groups, including alkynes, alkenes, benzylic ethers, and nitroarenes, remain intact under the coupling conditions.
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