期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 308, 期 1-2, 页码 160-167出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2005.11.004
关键词
porous CaCO3; layer-by-layer; polyelectrolyte multilayer films; encapsulation
Combination of adsorption by porous CaCO3 microparticles and encapsulation by polyelectrolyte multilayers via the layer-by-layer (LbL) self-assembly was proposed for sustained drug release. Firstly, porous calcium carbonate microparticles with an average diameter of 5 mu m were prepared for loading a model drug, ibuprofen (IBU). Adsorption of IBU into the pores was characterized by ultraviolet (UV), infrared (IR), thermogravimetric analysis (TGA), Brunauer-Emmett-Teller (BET) experiment and X-ray diffraction (XRD). The adsorbed IBU amount Gamma was 45.1 mg/g for one-time adsorption and increased with increasing adsorption times. Finally, multilayer films of prolamine sulfate (PRO) and sodium poly(styrene sulfonate) (PSS) were formed on the IBU-loaded CaCO3 n-ftroparticles by the layer-by-layer self-assembly. Amorphous IBU loaded in the pores of the CaCO3 microparticles had a rapider release in the gastric fluid and a slower release in the intestinal fluid, compared with the bare IBU crystals. Polyelectrolyte multilayers assembled on the drug-loaded particles by the LbL reduced the release rate in both fluids. In this work, polymer/inorganic hybrid core-shell microcapsules were fabricated for controlled release of poorly water-soluble drugs. The porous inorganic particles are useful to load drugs in amorphous state and the polyelectrolyte multilayer films coated on the particle assuage the initial burst release. (c) 2005 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据