期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 6, 页码 1852-1857出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0507198103
关键词
cardiac rejection; detection of single macrophage; micrometer-sized iron oxide particle; nanometer-sized iron oxide particle
资金
- NCRR NIH HHS [S10RR-15704] Funding Source: Medline
- NHLBI NIH HHS [F32HL-068423, F32 HL068423] Funding Source: Medline
- NIBIB NIH HHS [P41EB-001977, R01 EB000318, R01EB-00318, P41EB-00197, P41 EB001977] Funding Source: Medline
In vivo cell tracking by MRI can provide means to observe biological processes and monitor cell therapy directly. Immune cells, e.g., macrophages, play crucial roles in many pathophysiological processes, including organ rejection, inflammation, autoimmune diseases, cancer, atherosclerotic plaque formation, numerous neurological disorders, etc. The current gold standard for diagnosing and staging rejection after organ transplantation is biopsy, which is not only invasive, but also prone to sampling errors. Here, we report a noninvasive approach using MRI to detect graft rejection after solid organ transplantation. In addition, we present the feasibility of imaging individual macrophages in vivo by MRI in a rodent heterotopic working-heart transplantation model using a more sensitive contrast agent, the micrometer-sized paramagnetic iron oxide particle, as a methodology to detect acute cardiac rejection.
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