期刊
BRITISH JOURNAL OF CANCER
卷 94, 期 3, 页码 341-345出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602951
关键词
tankyrase; poly(ADP-ribosyl) ation; telomeres; telomerase
类别
The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase I modulates telomerase inhibition in human cancer cells and is reviewed in this report as a potential telomere-directed anticancer target.
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