Optical sensor arrays: one-pot, multiparallel synthesis and cellulose immobilization of pH and metal ion sensitive azo-dyes

A sixteen component array of acid-base and metal ion sensors was synthesized and covalently immobilized onto a transparent cell ulose-based membrane. Dye synthesis and cellulose dyeing were carried Out in one-pot, parallel, microscale reactions not requiring any isolation or purification steps. In addition, pH and metal ion optical sensing properties of the sixteen component array have been tested using a high-throughput screening based on digital imaging analysis. (c) 2005 Elsevier Ltd. All rights reserved.