期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 12, 期 6, 页码 928-934出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v12.i6.928
关键词
cycloxygenase-2 (COX-2); epithelial growth factor receptor (EGFR); Barrett's esophagus; carcinogenesis
AIM: To investigate the expression of cyclooxygenase-2 (COX-2) and epithelial growth factor receptor (EGFR) throughout the progression of Barrett's esophagus (BE). METHODS: COX-2 and EGFR protein expressions were detected by using immunohistochemical method. A detailed cytomorphological changes were determined. Areas of COX-2 and EGFR expression were quantified by using computer Imaging System. RESULTS: The expressions of both COX-2 and EGFR increased along with the progression from BE to esophagus adenocarcinoma (EAC). A positive correlation was found between COX-2 expression and EGFR expression. CONCLUSION: COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, thereby leading to carcinogenesis. (c) 2006 The WJG Press. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据