期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 7, 页码 2103-2108出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0508819103
关键词
cell mechanics; dynacortin; laser-based particle tracking; nanoscale
资金
- NIGMS NIH HHS [R01GM59285, R01 GM066817-04, R01 GM066817, R01 GM066817-03, R01 GM066817-02, R01 GM059285] Funding Source: Medline
Cell cortices rearrange dynamically to complete cytokinesis, crawl in response to chemoattractant, build tissues, and make neuronal connections. Highly enriched in the cell cortex, actin, myosin II, and actin crosslinkers facilitate cortical movements. Because cortical behavior is the consequence of nanoscale biochemical events, it is essential to probe the cortex at this level. Here, we use high-resolution laser-based particle tracking to examine how myosin II mechanochemistry and dynacortin-mediated actin cross-linking control cortex dynamics in Dictyostelium. Consistent with its low duty ratio, myosin II does not directly drive active bead motility. Instead, myosin II and dynacortin antagonistically regulate other active processes in the living cortex.
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