期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 4, 页码 954-959出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.10.107
关键词
AVP; vasopressin V-2 receptor agonists; diabetes insipidus; enuresis; nocturia
Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V-2 receptor selective agonists exemplified by the 5,11-dibydro-pyrido[2,3-b][1,5]benzodiazepine as a candidate for further development. (c) 2005 Elsevier Ltd. All rights reserved.
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