期刊
JOURNAL OF NEUROSCIENCE
卷 26, 期 7, 页码 2072-2079出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5042-05.2006
关键词
affect; arousal; learning and memory; emotional interference; emotional-cognitive interaction; affective disorders
资金
- NIMH NIH HHS [R01-MH05286, P50-MH60451] Funding Source: Medline
- NINDS NIH HHS [P01-NS41328] Funding Source: Medline
Flexible behavior depends on our ability to cope with distracting stimuli that can interfere with the attainment of goals. Emotional distracters can be particularly disruptive to goal-oriented behavior, but the neural systems through which these detrimental effects are mediated are not known. We used event-related functional magnetic resonance imaging to investigate the effect of emotional and nonemotional distracters on a delayed-response working memory (WM) task. As expected, this task evoked robust activity during the delay period in typical WM regions (dorsolateral prefrontal cortex and lateral parietal cortex). Presentation of emotional distracters during the delay interval evoked strong activity in typical emotional processing regions (amygdala and ventrolateral prefrontal cortex) while simultaneously evoking relative deactivation of the WM regions and impairing WM performance. These results provide the first direct evidence that the detrimental effect of emotional distracters on ongoing cognitive processes entails the interaction between a dorsal neural system associated with cold executive processing and a ventral system associated with hot emotional processing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据