期刊
CANCER
卷 106, 期 4, 页码 789-795出版社
JOHN WILEY & SONS INC
DOI: 10.1002/cncr.21675
关键词
prostatic neoplasms; ethnicity; longitudinal analysis
类别
资金
- PHS HHS [P50 C89520] Funding Source: Medline
BACKGROUND. Few Studies of ethnicity and prostate cancer have included Latino men in analyses of baseline clinical characteristics, treatment selection, and disease-free survival (DFS). The present study examines the impact of Latino ethnicity, on these parameters in a large, In multiinstitutional database of men with prostate cancer. METHODS. We compared baseline disease characteristics and clinical Outcomes for Latino (N = 138), non-Latino White (NLW, N = 5619), and African-American (AA, N = 608) men with localized prostate cancer by using chi-square and ANOVA for baseline variables and survival analysis to examine differences ill time to recurrence. RESULTS. Latino men resembled AA men more than NLW on sociodemographic characteristics. AA men had higher Gleason scores and prostate-specific antigen (PSA) at diagnosis than Latino or NLW men (both P < 0.01). 10% of both Latino and AA men presented with advanced disease (T3b/T4/N+/M+) versus 4% of NLW (P < 0.01). Latino men did not receive different treatments than NLW or AA men after controlling for clinical and demographic factors; however, AA men were more likely to receive external beam radiation (OR = 1.51, 95% confidence interval [CI] = 0.99-2.31) and hormone treatment (OR = 1.56, 95% CI = 1.05-2.32) then NLW men. For prostatectomy patients, 3-year actuarial DFS rates were 83% for NLW men and 86% for Latino men versus 69% for AA men (P < 0.01). After controlling for clinical and sociodemographic variables, AA men were somewhat more likely than NLW to experience disease recurrence after radical prostatectonly (RP) (FIR = 1.38, 95% CI = 0.98-1.94, P = 0.06). CONCLUSIONS. Latinos are more similar to African Americans on sociodemographic characteristics but more similar to NLW on clinical presentation, treatments received, and DFS.
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