期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 4, 页码 1032-1036出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.10.082
关键词
thrombin; inhibitor; trypsin; phenol; sulfonamide
Prototypical thrombin inhibitors were synthesized based on a trisubstituted phenol as a core motif. A naphthylsulfonamide analogue showed excellent antithrombin activity. An X-ray co-crystal structure showed the expected interactions. (c) 2005 Elsevier Ltd. All rights reserved.
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