期刊
CARDIOVASCULAR RESEARCH
卷 69, 期 3, 页码 574-584出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.cardiores.2005.09.004
关键词
metalloproteinases; membrane-type metalloproteinases; integrins; ADAMs; disintergrins; cardiac remodeling
资金
- NHLBI NIH HHS [HL73393, T32 HL007444, HL57872] Funding Source: Medline
The concept of myocardial remodeling links an initial pathological insult to a progressive geometric change of the ventricle. Currently, our concepts of the remodeling process have evolved to include not only changes in ventricular size and shape, but cellular and molecular remodeling, particularly as the ventricle evolves towards failure. In recent years, much attention has focused on the role of cell-extracellular matrix (ECM) connections in this process. In this review, we will specifically delineate how cell membrane-linked molecules of three classes: integrins, membrane-type matrix metalloprotemases, and ADAMs (A Disintegrin And Metalloprotemase) might play crucial roles in myocardial remodeling. These molecules are essential for cell-ECM adhesion, cell signaling, matrix modification, and proteolysis of surface receptors. Our goal is to put forth concepts on how they might interrelate to modulate the remodeling process in the heart. European Society of Cardiology. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据