期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 531, 期 1-3, 页码 103-107出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2005.12.012
关键词
antianalgesia; analgesia; opioid; spinal cord; knockout mice
资金
- NIDA NIH HHS [DA 12588] Funding Source: Medline
We have demonstrated that the antianalgesia induced by dextro-morphine and levo-morphine, is not mediated by the stimulation of mu-opioid receptors in male CD-1 mice. We now report that the dextro-morphine and levo-morphine attenuated antinociception produced by delta-opioid receptor agonist deltorphin II and K-Opioid receptor agonist U50,488H given spinally in the male mu-opioid receptor knockout mice. The tail-flick response was used for the antinociceptive test. Intrathecal injection of levo-morphine (3 time]) markedly inhibited the tail-flick response in wild type, partially in heterozygous, but not in homozygous mu-opioid receptor knockout mice. Intrathecal pretreatment with dextro-morphine (33 fmol) or levo-morphine (0.3 nmol) for 45 min also attenuated levo-m\orphine-produced antinociception in wide type mice. Intrathecal pretreatment with dextro-morphine (33 fmol) or levo-morphine (0.3 nmol) for 45 min attenuated the tail-flick inhibition produced by deltorphin II (12.8 nmol) and U50,488H (123.3 nmol) in wide type, heterozygous and homozygous mu-opioid receptor knockout mice. The findings provide additional evidence that mu-opioid receptors are not involved in the antianalgesia induced by dextro-morphine and levo-morphine. (c) 2005 Elsevier B.V. All rights reserved.
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