期刊
ORGANIC LETTERS
卷 8, 期 4, 页码 581-584出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol052655g
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资金
- NCI NIH HHS [R01 CA083831-04, R01 CA083831-06, R01-CA83831, R01 CA083831, R01 CA083831-05] Funding Source: Medline
Fluorescent small molecules are powerful tools for exploring cellular biology. As a more hydrophobic, photostable, and less pH-sensitive alternative to fluorescein, we synthesized Pennsylvania Green, a bright, monoanionic fluorophore related to Oregon Green and Tokyo Green. Comparison of membrane probes comprising N-alkyl-3 beta-cholesterylamine linked to 4-carboxy-Tokyo Green (pK(a) similar to 6.2) and 4-carboxy-Pennsylvania Green (pK(a) similar to 4.8) revealed that only Pennsylvania Green was highly fluorescent in acidic early and recycling endosomes within living mammalian cells.
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