The preparation of iodo-substituted aryl, heteroaryl, or cycloalkenyl ketones as silylated cyanohydrins allows the smooth performance of an I/Mg-exchange using i-PrMgCl center dot LiCl. A facile deprotection of the resulting functionalized products obtained by a reaction with electrophiles (acid chlorides, allylic bromide, benzylidene-p-toluenesulfonamide, and 3-iodocyclohexenone) produces polyfunctional ketones in good overall yields. This sequence can be extended to aromatic iodoaldehydes. In these cases, the deprotection of the silylated cyanohydrin functionality is best performed with aqueous CuSO4 under basic conditions.
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