期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 110, 期 6, 页码 2471-2474出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp056865m
关键词
-
资金
- NIBIB NIH HHS [R01 EB00739-01] Funding Source: Medline
The synthesis and characterization of calcium carbonate microparticles by reaction of calcium chloride and ammonium bicarbonate in the presence of negatively charged phospholipid mixtures of negative and zwitterionic phospholipids has been reported. Negatively charged phospholipids influence the crystal morphology of calcium carbonate and induce the formation of thermodynamically less stable veterite polymorph as opposed to calcite polymorph. The phospholipids are entrapped in the calcium carbonate microparticles during the crystallization process, with a uniform distribution of phospholipids in the interior of the microparticles. This phenomenon was exploited to encapsulate a model hydrophobic fluorophore, the tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride complex, to simulate encapsulation of hydrophobic drug molecules. Thermogravimetric analysis reveals that, in these microparticles, the calcium carbonate and the phospholipid exhibit strong interactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据