期刊
CIRCULATION RESEARCH
卷 98, 期 3, 页码 E20-E25出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.RES.0000205765.28940.93
关键词
endothelial progenitor cells; CD34/CD133; arterial injury; reendothelialization; atherosclerosis
Our goal was to identify functionally important subpopulations within the heterogenous group of endothelial progenitor cells (EPC). Fluorescence-activated cell sorter analysis of CD133(+) progenitor cells revealed the presence of CD34(+) and CD34(-) subpopulations. CD34(-)/133(+) progenitors differentiate into CD34(+)/133(+) EPC, adhere more potently than these in response to SDF-1, and rapidly home to sites of limb ischemia in human volunteers. In human coronary atherectomy samples, fewer CD34(-)/133(+) than CD34(+)/133(+) EPC are present in stable plaques, whereas cell numbers increase with a reversion of the ratio in unstable lesions. In CD34(-)/133(+) EPC-injected nude mice, more transplanted cells coexpressing endothelial markers home to carotid artery lesion endothelium than in CD34(+)/133(+)-injected mice. In the former, lesions were smaller and reendothelialization higher than in the latter. We identified a new CD34(-)/133(+) EPC subpopulation, which is apparently a precursor of classical CD34(+)/133(+) EPC, and functionally more potent than these with respect to homing and vascular repair.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据