期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 103, 期 3, 页码 455-460出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2005.08.038
关键词
Cistus laurifolius; Cistaceae; flavonoid; hepatotoxicity; lipid peroxidation; serum transaminase enzymes; cellular GSH
In this study, the effect of the flavonoids quercetin-3-methyl-ether-(isorhamnetin) (1). quercetin-3,7-dimethyl-ether (2) and kaempferol-3,7-dimethyl-ether (3) isolated from Cistus laurifolius L. (cistaceae) leaves was assessed oil lipid peroxidation (fiver and plasma), cellular glutathione (GSH) level and plasma AST (aspartate aminotransferase), ALT (alanine aminotransferase) enzyme activities in acetaminophen-induced liver damage in mice. At 114 mg/kg oral dose quercetin-3,7-dimethyl-ether was shown to possess potent antioxidative activity. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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