期刊
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
卷 47, 期 4, 页码 742-748出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacc.2005.11.030
关键词
-
OBJECTIVES We explored the stimulus for B-type natriuretic peptide (BNP) secretion in the clinical setting of heart failure (HF). BACKGROUND Increasingly, plasma BNP levels arc being incorporated into the clinical assessment and management of systolic heart failure (SHF) as well as diastolic heart failure (DHF). However, heterogeneity in BNP levels among individuals with HF can cause some confusion ill interpreting results. METHODS In 160 consecutive patients presenting with HF, we measured plasma BNP levels and performed echocardiography and cardiac catheterization. Systolic and diastolic meridional wall stress was calculated from echocardiographic and hemodynamic data. RESULTS Although plasma BNP had a significant correlation (r(2) = 0.296 [p < 0.001]) with left ventricular end-diastolic pressure (EDP) as previously, reported, the correlation between plasma BNP and end-diastolic wall stress (EDWS) (r(2) = 0.987 [p < 0.001]) was more robust. In a subanalysis of 62 patients with DHF, a similar result was obtained (r(2) = 0.143 for EDP and r(2) = 0.704 for EDWS). In a comparison between SHF and DHF, the BNP level was significantly higher in SHF (p < 0.001.). Although EDP did not show any difference, EDWS was significantly higher in SHF than in DHF (p < 0.001). CONCLUSIONS The present study shows that plasma BNP levels reflect left ventricular EDWS more than any other parameter previously reported, not only in patients with SHF, but also in patients with DHF. The relationship of left ventricular EDWS to plasma BNP may provide a better fundamental understanding of the interindividual heterogeneity in BNP levels and their clinical utility in the diagnosis and management of HF.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据