期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 532, 期 3, 页码 265-269出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2005.12.081
关键词
neonatal treatment; citaloprain; imipramine; locomotor activity; sexual behavior
资金
- NCRR NIH HHS [P20 RR17701, P20 RR017701-057304, P20 RR017701-057300, P20 RR017701] Funding Source: Medline
Neonatal exposure to antidepressants, including selective serotonin reuptake inhibitors such as citalopram, induces behavioral disturbances which persist in mature rats. These disturbances have been proposed to model the symptoms of endogenous depression. However, to date there is scant evidence for the predictive validity of any of these behaviors in response to adult antidepressant treatments. In order to directly assess the predictive validity of the early antidepressant exposure paradigm, the present study examined whether the behavioral abnormalities observed in adult animals exposed as neonates to citalopram can be reversed by adult antidepressant treatment with the prototypic antidepressant, imipramine. As noted earlier, neonatal citalopram exposure robustly increased locomotor activity and impaired male sexual behavior in adult rats. These behavioral changes were reversed following chronic adult imipramine treatment. No such reversal was observed in handled, saline treated rats. The present data support the hypothesis that some of the lasting behavioral abnormalities induced by early antidepressant exposure are sensitive to clinically relevant antidepressant treatments thus adding a measure of predictive validity to this paradigm as a model of these depressive symptoms. (c) 2006 Elsevier B.V. All rights reserved.
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