期刊
TETRAHEDRON LETTERS
卷 47, 期 9, 页码 1457-1460出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.12.083
关键词
N-tert-butyl-N-chlorocyanamide; aldoximes; hydroximoyl chlorides; N-phenylmaleimide; dipolarophiles; 2-isoxazolines
Treatment of aldoximes with N-tert-butyl-N-chlorocyanamide gave hydroximoyl chlorides in quantitative yields in less than a minute, which on dehydrohalogenation in the presence of triethylamine gave the corresponding nitrile oxides. The nitrile oxides underwent 1,3-dipolar addition to dipolarophiles and gave 2-isoxazolines in excellent yields under mild conditions. (c) 2005 Elsevier Ltd. All rights reserved.
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