期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 38, 期 1, 页码 1-10出版社
KOREAN SOC MED BIOCHEMISTRY MOLECULAR BIOLOGY
DOI: 10.1038/emm.2006.1
关键词
beta catenin; protein interaction mapping; protein processing; post-translational; TCF transcription factors; Wnt proteins
The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic beta-catenin and then the accumulated beta-catenin is translocated into the nucleus, where it activates the transcriptional factor T-cell factor (Tcf)/lymphoid enhancer factor (Lef), and thereby stimulates the expression of genes including c-myc, c-jun, fra-1, and cyclin D1. Tight regulation of this response involves post-translational modifications of the components of the Wnt signaling pathway. Phosphorylation, ubiquitination, and sumoylation have been shown to affect the half-life of beta-catenin and the transcriptional activity of Tcf/Lef. The precise spatio-temporal patterns of these multiple modifications determine the driving force of various cellular responses.
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