期刊
BEHAVIOURAL BRAIN RESEARCH
卷 167, 期 2, 页码 379-382出版社
ELSEVIER
DOI: 10.1016/j.bbr.2005.09.014
关键词
place conditioning; in vivo microdialysis; dopamine; SHR rat; nucleus accumbens; psychostimulants
We used a putative animal model of attention deficit hyperactivity disorder (ADHD), the SHR rat, to examine the effects of repeated exposure to methylphenidate (MPH; Ritalin (R)) during the pubertal period on cocaine-induced conditioned place preference and dopamine (DA) levels in the nucleus accumbens (NAc) in adulthood. Our results indicate that early exposure to methylphenidate diminishes sensitivity to the incentive properties of cocaine in adulthood, but it does so without altering the response of the mesolimbic dopamine system. (c) 2005 Elsevier B.V. All rights reserved.
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