期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 103, 期 9, 页码 3090-3093出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0511050103
关键词
Asf1; histones; Nap1; RSC; yeast
资金
- NIGMS NIH HHS [GM36659, R01 GM036659, R37 GM036659] Funding Source: Medline
The RSC chromatin-remodeling complex completely disassembles a nucleosome in the presence of the histone chaperone Nap1 and ATP. Disassembly occurs in a stepwise manner, with the removal of H2A/H2B dimers, followed by the rest of the histones and the release of naked DNA. RSC and related chromatin-remodeling complexes may be responsible for the removal of promoter nucleosomes during transcriptional activation in vivo.
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