Expanding indications for the treatment of pulmonary artery stenosis in children by using cutting balloon angioplasty

Objectives : To evaluate the role of cutting balloon angioplasty in children with pulmonary artery stenosis. Background: Pulmonary artery stenoses can be either congenital or secondary to postoperative scar formation. Isolated multiple small-vessel pulmonary artery stenoses are very rare. No surgical procedures for their treatment are currently available. Methods: We report on four patients in whom standard and high-pressure balloon angioplasty had failed. Three of the four (2.5-, 3-, and 3.5-years-old; two girls) had isolated multiple peripheral pulmonary artery stenosis. The fourth patient was an 11-month-old girl (8 kg) with tetralogy of Fallot and hypoplastic pulmonary artery branches treated with the implantation of two stents in the pulmonary arteries. During the follow-up this patient developed severe intrastent restenosis and showed severely hypoplasic distal left pulmonary artery. Results: We treated 11 vessels. The mean vessel diameter increased by 81% (P < 0.0001) and RV/LV pressure ratio decreased from 1.15 to 0.75 (P = 0.05). Patient treated for intrastent restenosis underwent successful complete tetralogy of Fallot repair. None of the patients suffered procedure-related complications. At a median follow-up of 18 months, results were stable and no late complications had occurred. Conclusions: Cutting balloon angioplasty is a promising technique for the treatment of highly challenging pathologies such as small vessel pulmonary artery stenoses and intrastent restenosis. (c) 2006 Wiley-Liss, Inc.