期刊
CANCER AND METASTASIS REVIEWS
卷 25, 期 1, 页码 99-113出版社
SPRINGER
DOI: 10.1007/s10555-006-7893-x
关键词
extracellular matrix (ECM); matrix metalloproteinase (MMP); tissue inhibitor of metalloproteinase (TIMP); apoptosis; tetraspanin; integrin
类别
资金
- NCI NIH HHS [CA89113] Funding Source: Medline
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of matrix metalloproteinases (MMPs) and the balance between MMPs/TIMPs regulates the extracellular matrix (ECM) turnover and remodeling during normal development and pathogenesis. Increasing evidence indicates a much more complex role for TIMPs during tumor progression and angiogenesis, in addition to their regulation of MMP-mediated ECM degradation. In this article, we review both the MMP-dependent and -independent actions of TIMPs for the regulation of cell death, cell proliferation, and angiogenesis, with a particular emphasis on TIMP-1 in the regulation of tetraspanin/integrin-mediated cell survival signal transduction pathways.
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