期刊
JOURNAL OF NATURAL PRODUCTS
卷 69, 期 3, 页码 436-438出版社
AMER CHEMICAL SOC
DOI: 10.1021/np050418g
关键词
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A new pyridone alkaloid, (+)-N-deoxymilitarinone A (1), was isolated from Paecilomyces farinosus RCEF 0097 along with the related metabolites, militarinone D and militarinone B. The sterol 22E,4R-ergosta-7,22-diene-3 beta,5 alpha,6 beta,9 alpha-tetraol was also identified. The structures were established by spectroscopic methods, in particular with the aid of extensive NMR experiments. Compound 1 induced neurite sprouting in PC 12 cells when tested at 33 and 100 mu M concentrations. A cytotoxic effect was observed in human neurons (IMR-32) at a concentration of 100 mu M.
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