期刊
JOURNAL OF SEPARATION SCIENCE
卷 29, 期 5, 页码 695-698出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200500430
关键词
capillary gas chromatography; high throughput; low thermal mass column oven; pharmaceutical analysis; residual solvents
A low thermal mass column oven was used for fast capillary GC analysis (high throughput) of residual solvents in pharmaceutical products. A dedicated capillary column, 20 m L x 180 mu m ID x 1 mu m DB-624 was programmed from 35 degrees C (30 s) to 150 degrees C at 100 degrees C/min and to 250 degrees C (30 s) at 200 degrees C/min, resulting in a total GC cycle time of less than 4 min. Complete separation of a target 20-component mixture was achieved, while method performance in terms of repeatability, sensitivity, and linearity was maintained in comparison to the generic method currently applied in our laboratories.
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