期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 23, 期 7, 页码 537-541出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1066896915586807
关键词
gastric cancer; osteoclast-like giant cells (OGCs); immunoprofiling; molecular profiling
Here we present the case of a 73-year-old woman with an ulcerated, advanced, hepatoid, and -fetoprotein-producing poorly differentiated (G3) primary gastric adenocarcinoma pT3 N3a M1 with multinucleated cells and evident neuroendocrine component. This tumor was consistent with giant cell tumor type gastric carcinoma with osteoclast-like giant cells (OGCs). The cancer was HER2 and E-cadherin negative, chromogranin A dispersedly and moderately positive, and strongly -fetoprotein-positive with evident CK AE1/AE3 immunoreactivity, while OGCs expressed CD68. To provide an insight into the molecular background of this peculiar neoplasm, next-generation sequencing (NGS) was performed to analyze the 50 most frequently mutated oncogenes and tumor suppressors. We detected mutations in the primary tumor in the following genes: KIT, EGFR, PTEN, ATM, and RB1. In the liver metastasis, we revealed mutations in 3 genes: PIK3CA, KIT, and CDKN2A.
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