期刊
JOURNAL OF NEURAL TRANSMISSION
卷 113, 期 3, 页码 381-385出版社
SPRINGER WIEN
DOI: 10.1007/s00702-005-0335-z
关键词
schizophrenia; TRAR4; family-based; variants; UTR; variants
The TRAR4 gene locates in SCZD5 (MIM 603175), which a number of studies have linked with schizophrenia. One recent study suggested that three TRAR4 variants (M1: rs4305745, P = 0.0014; M2: rs6903874, P = 0.0026; M3: rs6937506, P = 0.0052) in the 3'-UTR were associated with schizophrenia. To replicate these findings, we conducted a family-based association study within a sample of 235 Chinese Han trios. However, we didn't find significant evidence of preferential transmission of the three variants across all the trios (all P values > 0.2). Thus, we conclude that TRAR4 is not a major or independent determinant in the occurrence of schizophrenia in the Chinese Han population.
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