期刊
EUROPEAN RESPIRATORY JOURNAL
卷 27, 期 3, 页码 547-555出版社
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09031936.06.00062705
关键词
chronic obstructive pulmonary disease; exacerbations; health resource utilisation; peak expiratory flow; tiotropium
This randomised, double-blind, parallel-group, 1-yr study compared the effect of tiotropium 18 mu g once daily (n = 500) and placebo (n = 510) on exacerbations, associated health resource use (HRU) and airflow limitation in chronic obstructive pulmonary disease (COPD) patients. The mean +/- SD number of exacerbations during the past year was 2.14 +/- 1.40, the mean weekly morning peak expiratory flow (PEF) was 259.6 +/- 96.1 L center dot min(-1) and the mean forced expiratory volume in one second (FEV1) was 1.37 +/- 0.45 L. Tiotropium significantly delayed the time to first exacerbation by similar to 100 days, reduced the proportion of patients experiencing more than one exacerbation by 17%, and decreased the number of exacerbations by 35% and exacerbation days by 37% versus placebo. Tiotropium also decreased HRU versus placebo, as indicated by the significant reductions in the use of concomitant respiratory medications, antibiotics and oral steroids, and the number of unscheduled physician contacts. Mean weekly morning PEF improved significantly with tiotropium versus placebo from week 1 until the end of the study. At the end of the study, tiotropium significantly improved trough (pre-dose) FEV1, forced vital capacity, slow vital capacity and inspiratory capacity versus placebo. In conclusion, tiotropium reduced exacerbations and associated health resource use, and improved airflow over 1 yr in chronic obstructive pulmonary disease patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据