期刊
HYPERTENSION
卷 47, 期 3, 页码 515-521出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/01.HYP.0000196268.08909.fb
关键词
hypertension; receptors, angiotensin; angiotensin converting enzyme; angiotensin II
资金
- NHLBI NIH HHS [HL-51952, HL-6835] Funding Source: Medline
This lecture summarizes the chronology and rationale that led to the discovery of angiotensin-(1-7) as a hormone that, in its own right, opposes the vasoconstrictor and proliferative actions of angiotensin II. The work discussed here additionally analyzes the newest findings on angiotensin- converting enzyme 2, the angiotensin- converting enzyme homologue that efficiently hydrolyzes angiotensin II into angiotensin-(1-7). Both components of this system may significantly influence our future perspective of the role of the renin-angiotensin system, not just in terms of its role in the regulation of cardiovascular and renal function but, moreover, as regulators of a vast array of disease processes in which inflammation and immune mechanisms play a role.
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