期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 116, 期 3, 页码 735-742出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI26190
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资金
- NCI NIH HHS [CA109232, R01 CA109232] Funding Source: Medline
Kaposi sarcoma-associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in AIDS patients. The KSHV latency-associated nuclear antigen (LANA) is consistently expressed in all KSHV-associated tumor cells and was shown to bind the tumor suppressor proteins p53 and pRb. To test LANAs contribution to lymphomagenesis in vivo vie generated transgenic mice expressing LANA under the control of its own promoter, which is B cell specific. All of the transgenic mice developed splenic follicular hyperplasia due to an expansion of IgM(+)IgD(+)B cells and showed increased germinal center formation. We also observed lymphomas, implying that LANA can activate B cells and provide the first step toward lymphomagenesis.
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