期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 172, 期 1-2, 页码 73-84出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.11.003
关键词
autoimmunity; EAE; CTLA-4; remission; secondary progressive chronicity
Multiple sclerosis (MS) is often characterized by several relapses and remissions during long-term disease, but neither the responsible cells nor the mechanisms are known to date. Using an animal model of multiple sclerosis, relapsing experimental autoimmune encephalomyelitis (R-EAE) CD4(+)CD25(+) T-reg Cells expressing Foxp3 and CTLA-4 intracellularly and T lymphocytes expressing surface CTLA-4 were identified in the CNS. The first remission occurred even after depletion of T-reg cells, but secondary remissions from EAE were ablated. Despite the unaltered first remission autoantigen rechallenge revealed already an amplified cytokine response during acute phase. These results indicate that the cellular composition during first attack of MS predicts long-term disease progression. (C) 2005 Elsevier B.V. All rights reserved.
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