期刊
THEORETICAL POPULATION BIOLOGY
卷 69, 期 2, 页码 145-153出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.tpb.2005.07.002
关键词
host-parasite; evolution of virulence; viral dynamics; within-host selection; selection conflict
资金
- NIGMS NIH HHS [GM63882] Funding Source: Medline
Natural selection acts on virus populations at two distinct but interrelated levels: within individual hosts and between them. Studies of the evolution of virulence typically focus on selection acting at the epidemiological or between-host level and demonstrate the importance of trade-offs between disease transmission and virulence rates. Within-host studies reach similar conclusions regarding trade-offs between transmission and virulence at the level of individual cells. Studies which examine selection at both scales assume that between and within-host selection are necessarily in conflict. We explicitly examine these ideas and assumptions using a model of within-host viral dynamics nested within a model of between-host disease dynamics. Our approach allows us to evaluate the direction of selection at the within- and between-host levels and identify situations leading to conflict and accord between the two levels of selection. (c) 2005 Elsevier Inc. All rights reserved.
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