期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 15, 期 3, 页码 307-315出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543784.15.3.307
关键词
endocannabinoids; metabolic syndrome; obesity; rimonabant; smoking; SR-141716
Rimonabant is the first selective blocker of the cannabinoid CB1 receptors being developed for the treatment of obesity, tobacco smoking and cardiometabolic risk factors. Following 1 year of treatment, rimonabant 20 mg/day leads to greater weight loss compared with placebo. Therapy with rimonabant is also associated with favourable changes in serum lipids and an improvement in glycaemic control in Type 2 diabetics. At the same dose, rimonabant significantly increases the cigarette smoking quit rates compared with placebo. Rimonabant appears to be generally well tolerated, with primary side effects of mild nausea, diarrhoea, anxiety and depression. As an agent with a novel mechanism of action, rimonabant has the potential to be a useful adjunct to lifestyle modification in the treatment of obesity, metabolic syndrome and cigarette smoking.
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