期刊
PHYTOCHEMICAL ANALYSIS
卷 17, 期 2, 页码 102-106出版社
WILEY
DOI: 10.1002/pca.892
关键词
GC-EI/MS; dereplication; pentacyclic triterpenoids; anti-tubercular activity
资金
- FIC NIH HHS [5 UO1 TW000316-10] Funding Source: Medline
Three common plant-derived pentacyclic triterpenoids, oleanolic acid (1), betulinic acid (2) and ursolic acid (3), have been found to exhibit moderate anti-tubercular activity in a microplate alamar blue assay. In order to facilitate the discovery of novel antitubercular leads with diverse chemical structures, a new and rapid GC-EI/MS method was developed simultaneously and unambiguously to dereplicate 1-3 as their methyl esters with limits of detection of 25.6, 26.9 and 26.8 ng, respectively. Copyright (C) 2005 John Wiley & Sons, Ltd.
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